Countermeasures Against Organophosphorus Nerve Agents – Reactivation of Acetylcholinesterase
Organophosphate nerve agents, such as sarin gas, bind irreversibly to the enzyme acetylcholinesterase. The phosphylated enzyme is completely nonfunctional which leads to a toxic accumulation of the neurotransmitter acetylcholine.



Current antidotes utilize nucleophilic oximes to reactivate acetylcholinesterase by competitively binding to the phosphorous.

Representative Publication

Gambino, A., Burnett, J. C., & Koide, K. ACS Med. Chem. Lett. 2020, 11, 1893–1898.