Improved Synthesis of the Amine Fragment of FR901464 and Thailanstatins through the Development of a Convenient N-Detosylation Method 
Beard, J. P., Emerson, J. D., Jacobs, A. S., O’Grady, A. J., Burrows, J., & Koide, K. J. Org. Chem. 202287, published online.

Mono-O-functionalizations of Pittsburgh Green and Their Applications
Vinod, J. K. & Koide, K. Eur. J. Org. Chem. 2022, e202200343.

Fluorometric Study on the amine-catalysed Suzuki–Miyaura coupling
Vinod, J. K., Wanner, A. K., James, E. I., & Koide, K. Nat. Catal. 2021,
Click here for online-view-only version.

Scalable Birch reduction with lithium and ethylenediamine in tetrahydrofuran
Burrows, J., Kamo, S., & Koide, K. Science 2021, 374, 741.

Catalysis-Based Fluorometric Method for Trace Palladium Detection with Improved Convenience
Williams, J. M., Wanner, A. K., & Koide, K. Org. Process Res. Dev. 2020, 24, 2941-2949.

Using Ligand-Accelerated Catalysis to Repurpose Fluorogenic Reactions for Platinum or Copper
Pham, D., Deter, C. J., Reinard, M. C., Gibson, G. A., Kiselyov, K., Yu, W., Sandulache, V. C., St Croix, C., Watkins, S. C., & Koide, K. ACS Cent. Sci. 2020, 6, 1772–1788.

Fluorogenic Probe Using a Mislow‐Evans Rearrangement for Real‐Time Imaging of Hydrogen Peroxide
Pham, D., Basu, U., Pohorilets, I., St Croix, C., Watkins, S. C., & Koide, K. Angew. Chem. Int. Ed. 202059, 17435–17441.

Total Synthesis of Meayamycin B
Bressin, R. K., Osman, S., Pohorilets, I., Basu, U., & Koide, K. J. Org. Chem. 2020, 85, 4637–4647.
Highlighted in Organic Chemistry Portal, 2021/02 !

Methyl Scanning and Revised Binding Mode of 2-Pralidoxime, an Antidote for Nerve Agent Poisoning
Gambino, A., Burnett, J. C., & Koide, K. ACS Med. Chem. Lett. 202011, 1893–1898.

Third-Generation Method for High-Throughput Quantification of Trace Palladium by Color or Fluorescence
Lukomski, L., Pohorilets, I., & Koide, K. Org. Process Res. Dev. 2020, 24, 85–95.

Kinetic and Inverse Temperature Dependence of a Tsuji-Trost Reaction in Aqueous Buffer
Pohorilets, I., Tracey, M. P., LeClaire, M. J., Moore, E. M., Lu, G., Liu, P., & Koide, K. ACS Catal. 20199, 11720–11733.

Scalable Preparations of Methylated Ando-Type Horner-Wadsworth-Emmons Reagent
Bressin, R. K., Driscoll, J. L., Wang, Y., & Koide, K. Org. Process Res. Dev. 201923, 274–277.

Total Synthesis of the Reported Structure of Stresgenin B Enabled by the Diastereoselective Cyanation of an Oxocarbenium
Chan, W. C. & Koide, K. Org. Lett. 2018, 20, 7798–7802.
One of top 20 most downloaded papers for the month of December, 2018 ! Highlighted in Synfacts 2019/03 !

Noneffervescent Method for Catalysis-Based Palladium Detection with Color or Fluorescence
Nieberding, M., Tracey, M. P., & Koide, K. ACS Sens. 20172, 1737–1743.

Synthesis of Violaceic Acid and Related Compounds through Aryl Triazene.
Ando, S., Burrows, J. & Koide, K. Org. Lett. 201719, 1116–1119.

Online Sensing of Palladium in Flowing Streams.
Bu, X. D., Williams, M., Jo, J., Koide, K. & Welch, C. J. Chem. Commun. 2017, 53, 720–723.

A Competitive and Reversible Deactivation Approach to Catalysis Based Quantitative Assays.
Koide, K., Tracey, M.P., Bu, X., Jo, J., Williams, M.J. & Welch, C.J. Nat. Commun20167, 10691

Influenza Virus mRNA Trafficking through Host Nuclear Speckles
Mor, A., White, A., Zhang, K. Thompson, M., Esparza, M., Muñoz-Moreno, R., Koide, K., Lynch, K. W., García-Sastre, A., & Fontoura, B. M. A. Nat. Microbiol. 20161, 16069.

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.
Schreiber, C.A., Sakuma, T., Izumiya, Y., Holdich, S.J., Hickey, R.D., Bressin, R.K., Basu, U., Koide, K., Asokan, A. & Ikeda, Y. PLoS Pathog. 201511, e1005082.

Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules.
Tracey, M.P., Pham, D., & Koide, K., Chem. Soc. Rev. 201544, 4769–4791.

Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells.
Gao, Y., Trivedi, S., Ferris, R.L., & Koide, K., Sci. Rep. 20144, 6098.


Smith, S.E., Williams, J.M. & Koide, K. Time-insensitive fluorescent sensor for human serum albumin and its unusual red shift. Anal. Chem. 2014, 86, 23322336.

Williams, J.M. & Koide, K. A high-throughput method to detect palladium in ores. Ind. Eng. Chem. Res. 2013, 52, 86128615.

Gao, Y. & Koide, K. Chemical perturbation of Mcl-1 pre-mRNA splicing to induce apoptosis in cancer cells. ACS Chem. Biol. 2013, 8, 895900.

Bu, X., Koide, K, Carder, E.J. & Welch, C.J. Rapid analysis of residual palladium in pharmaceutical development using a catalysis-based fluorometric method. Org. Process Res. Dev. 2013, 17, 108113.

Gao, Y., Vogt, A, Forsyth, C.J., & Koide, K. Comparison of splicing factor 3b inhibitors in human cells. ChemBioChem 2013, 14, 4952.

Osman, S. & Koide, K. Ruthenium-catalyzed olefin metathesis after tetra-n-butylammonium fluoride-mediated desilylation.Tetrahedron Lett. 2012, 53, 66376640.

Visconte, V., Rogers, H.J., Singh, J., Barnard, J., Bupathi, M., Traina, F., McMahon, J., Hakishima, H., Szpurka, H., Jankowska, A., Jerez, A., Sekeres, M.A., Sauntharajah, Y., Advani, A.S., Copelan, E., Koseki, H., Isono, K., Padgett, R.A., Osman, S., Koide, K, O’Keefe, C., Maciekewski, J.P. & Tiu, R.V. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood 2012, 120, 31733186.

Cook, M.P., Ando, S., & Koide, K. One-step synthesis of a fluorescein derivative and mechanistic studies” M. P. Cook, S. Ando, and K. Koide, Tetrahedron Lett. 2012, 53, 52845286.

Imamoto, K., Campbell, L.D., Doi, T. & Koide, K. A highly sensitive fluorescence method reveals the presence of palladium in a cross-coupling reaction mixture not treated with transition metals. L. D. Tetrahedron Lett. 2012, 53, 31473148.

Li, D., Campbell, L.D., Austin, B.A. & Koide, K. Detection of trace palladium in flasks and metal reagents using a fluorogenic Tsuji-Trost reaction. ChemPlusChem 2012, 77, 281283.

Leslie, A.K., Li, D. & Koide, K. Amine-promoted β-elimination of a β-aryloxy aldehyde for fluorogenic chemodosimeters. J. Org. Chem. 2011, 76, 68606865.

Koide, K., Osman, S., Garner, A.L., Song, F., Dixon, T., Geenberger, J.S., & Epperly, M.W. The use of 3,5,4′-tri-O-acetylresveratrol as a potential pro-drug for resveratrol protects mice from γ-irradiation-induced death” ACS Med. Chem. Lett. 2011, 2, 270274.

Ando, S., Grote, A.L. & Koide, K. Diastereoselective synthesis of diketopiperazine bis-α,β-epoxides” S. Ando, A. L. Grote, and K. Koide, J. Org. Chem. 2011, 76, 11551158.

Ando, S. & Koide, K.  Development and applications of fluorogenic probes for mercury(II) based on vinyl ether oxymercuration. J. Am. Chem. Soc. 2011, 133, 2556–2566.

Osman, S., Albert, B.J., Wang, Y., Li, M. Czaicki, N.L., & Koide K. Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.Chem.-Eur. J. 2011, 17, 895–904.

Osman, S., Waud, W.R., Gorman, G.S., Day, B.W. & Koide, K. Evaluation of FR901464 analogues in vitro and in vivo. Med. Chem. Commun. 2011, 2, 38–43.

Song, F., Carder, E.J., Kohler, C.C. & Koide, K. Studies toward an ideal fluorescence method to measure palladium in functionalized organic molecules: effects of sodium borohydride, temperature, phosphine ligand, and phosphate ions on kinetics. Chem.-Eur. J. 2010, 16, 13500–13508.

Albert, B.J., McPherson, P.A., O’Brien, K., Czaicki, N.L., DeStefino, V., Osman, S., Li, M., Day, B.W., Grabowski, P.J., Moore, M., Vogt, A. & Koide, K. Meayamycin inhibits pre-mRNA splicing and exhibits picomolar activity against multidrug resistant cells. Mol. Cancer Ther. 2009, 8, 2308–2318. 

Garner, A.L., St. Croix, C.M., Pitt, B.R., Leikauf, G.D., Ando, S. & Koide, K. Specific fluorogenic probes for ozone in biological and atmospheric samples. Nature Chem. 2009, 1, 316–321.

Garner, A.L., Song, F. & Koide, K. Enhancement of a catalysis-based fluorometric detection method for palladium through rational fine-tuning of the palladium species. J. Am. Chem. Soc. 2009, 131, 5163–5171.

Uchida, T., Mills, K.L., Kuo, C.-H., Roh, W., Tung, Y.-C., Garner, A.L., Koide, K., Thouless, M.D. & Takayama, S. External compression-induced fracture patterning on the surface of poly(dimethylsiloxane) cubes and microspheres. Langmuir 2009, 25, 3102–3107.

Garner, A.L. & Koide, K. Studies of a fluorogenic probe for palladium and platinum leading to a palladium-specific detection method. Chem. Commun. 2009, 86–88.

Garner, A.L. & Koide, K. Fluorescent method for platinum detection in buffers and serums for cancer medicine and occupational hazards. Chem. Commun. 2009, 83–85.

Song, F., Watanabe, S., Floreancig, P.E. & Koide, K. Oxidation-resistant fluorogenic probe for mercury based on alkyne oxymercuration. J. Am. Chem. Soc. 2008, 130, 16460–16461.

Garner, A.L & Koide, K. Oxidation state-specific fluorescent method for palladium(II) and platinum(IV) based on the catalyzed aromatic Claisen rearrangement. J. Am. Chem. Soc. 2008, 130, 16472–16473. 

Osman, S. & Koide, K. Cyclic acetal formation between 2-pyridinecarboxaldehyde and γ-hydroxy-α,β-acetylenic esters.Tetrahedron Lett. 2008, 49, 6550–6552.

Koide, K., Song, F., de Groh, E.D., Garner, A.L., Mitchell, V.D., Davidson, L.A. & Hukriede, N.A. Scalable and concise synthesis of dichlorofluorescein derivatives displaying tissue permeation in live zebrafish embryos. ChemBioChem 2008, 9, 214–218.

Albert, B.J. & Koide, K. Zirconium-promoted epoxy rearrangement-alkynylation sequence” B. J. Albert, K. Koide, J. Org. Chem. 2008, 73, 1093–1098.

Garner, A.L. & Koide, K. Solid-phase olefin cross-metathesis promoted by a linker” A. L. Garner, K. Koide, Org. Lett. 2007, 9, 5235–5238.

Koide, K. Synthesis and biological activity of antitumor natural product FR901464 and its analogue” K. Koide, Farumashia 2007, 43, 1183–1188.

Albert, B.J. & Koide, K. How rapidly do epoxides non-specifically form covalent bonds with thiols in water?ChemBioChem 2007, 8, 1912–1915

Song, F., Garner, A.L. & Koide, K. A highly sensitive fluorescent sensor for palladium based on the allylic oxidative insertion mechanism. J. Am. Chem. Soc. 2007,129, 12354–12355.

Sparano, B.A. & Koide, K. Fluorescent sensors for specific RNA: A general paradigm using chemistry and combinatorial biology. J. Am. Chem. Soc. 2007,129, 4785–4794.

Sonye, J.P. & Koide, K. Sodium bicarbonate-catalyzed stereoselective isomerizations of electron-deficient propargylic alcohols to (Z)-enones. J. Org. Chem. 2007, 72. 1846–1848.

Albert, B.J., Sivaramakrishnan, A., Naka, T., Czaicki, N.L. & Koide, K. Total synthesis, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue. J. Am. Chem. Soc. 2007, 129. 2648–2659.

Koide, K. & Alpert, B.J., Review: Total syntheses of FR901464. J. Synth. Org. Chem. Jpn. 2007, 65. 119–126

Koide, K. A new paradigm for the development of fluorescent RNA imaging technology using synthetic molecules. American Biotechnology Laboratory 2006, 24, 8–10

Sonye, J.P. & Koide, K. Base-catalyzed stereoselective isomerization of electron-deficient propargylic alcohols to E-enones”J. Org. Chem. 2006, 71. 6254–6257.

Albert, B.J., Sivaramkrishnan, A., Naka, T. & Koide, K. Total synthesis of FR901464, an antitumor agent that regulates the transcription of oncogenes and tumor suppressor genes. J. Am. Chem. Soc. 2006, 128. 2792–2793.

Sonye, J.P. & Koide, K. Organic base-catalyzed stereoselective isomerizations of 4-hydroxy-4-phenyl-but-2-ynoic acid methyl ester to (E)- and (Z)-4-oxo-4-phenyl-but-2-enoic acid methyl esters. Synth. Commun. 2006, 36, 599–602.

Sonye, J.P. & Koide, K. On the mechanism of DABCO-catalyzed stereoselective isomerization of g-hydroxy-a,b-alkynoates to gamma-oxo-alpha,beta-(E)-alkenoates” Org. Lett. 2006, 8, 199–202. 

Sparano, B.A. & Koide, K. A strategy for the development of small molecule-based sensors that strongly fluoresce when bound to a specific RNA. J. Am. Chem. Soc. 2005, 127, 14954–14955.

  • (Ranked 6th in the “Most-Accessed Articles: October-December, 2005” list)

Albert, B.J. & Koide, K. Synthesis of a C4-epi C1-C6 fragment of FR901464 using a novel bromolactolization. Org. Lett. 2004, 6, 3655–3658.

Sparano, B.A., Shahi, S.P. & Koide, K. Effect of binding and conformation on fluorescence quenching in new 2′,7′-dichlorofluorescein derivatives. Org. Lett., 2004, 6, 1947–1949. 

Meta, C.T. & Koide, K. Trans-selective conversions of gamma-hydroxy-alpha,beta-alkynoic esters to g-hydroxy-a,b-alkenoic esters. Org. Lett. 2004, 6, 1785–1787.

Shahi, S.P. & Koide, K. A mild method for the preparation of gamma-hydroxy-alpha,beta-acetylenic esters. Angew. Chem. Int. Ed. 2004, 43, 2525–2527.

Naka, T. & Koide, K. A novel and simple method to prepare g-hydroxy-a,b-(E)-alkenoic esters from g-keto-alkynoic esters.Tetrahedron Lett. 2003, 44, 443–445.

Graduate and Postdoctoral Work (1-15):

Koide, K., Finkelstein, J.M., Ball, Z. & Verdine, G.L. A synthetic library of cell-permeable molecules. J. Am. Chem. Soc. 2001, 123, 398.

Setyawan, J., Koide, K., Diller, T.C., Bunnage, M.E., Taylor, S.S., Nicolaou, K.C. & Brunton, L.L. Inhibition of protein kinases by balanol: Specificity within the serine/threonine protein kinase sub-family”, Mol. Pharm. 1999, 56, 370.

Narayana, N., Diller, T.C., Koide, K., Munnage, M.E., Nicolaou, K.C., Brunton, L.L., Xuong, N.-H., Ten Eyck Ten, L.F., & S.S. Taylor. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry 1999, 38, 2367.

Furukawa, H., Koide, K., Takao, & Kobayashi, S. Glycosyl 2-pyridinecarboxylate as an effective glycosyl donor: Glycosidation of mannose, 2-azidosugar, and 2-deoxysugar into disaccarides. Chem. Pharm. Bull. 1998, 46, 1244.

Nicolaou, K.C., Koide, K., Xu, J. & Izraelwicz, M.H. Synthetic studies on maduropeptin chromophore.  2.  Synthesis of the madurosamine aryl amide and the C1′-C9′ fragments.Tetrahedron Lett. 1997, 38, 3671.

Nicolaou, K.C., Koide, K., Khatuya, H. Synthetic studies on maduropeptin chromophore. 1. Construction of the aryl ether and attempted synthesis of the [7.3.0] bicyclic system.Tetrahedron Lett. 1997, 38, 3667.

Koide, K., Ohno, M., Kobayashi, S. Glycosyl fluoride for glycosidation promoted by a catalytic amount of gallium reagent. Synthesis 1996, 1175.

Koide, K., Bunnage, M.E., Gomez Paloma, L., Kanter, J.R., Taylor, S.S., Brunton, L.L. & Nicolaou K.C. Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.Chem. Biol. 1995, 2, 601.

Nicolaou, K.C., Koide, K., & Bunnage, M.E. Total synthesis of balanol and designed analogues. Chem. Eur. J. 1995, 1, 454.

Nicolaou, K.C., Piscopio, A.D., Bertinato, P., Minowa, N., Chakraborty, T.K. & Koide, K. Total synthesis of rapamycin. Chem. Eur. J. 1995, 1, 316.

Nicolaou, K.C., Tiebes, J., Theodorakis, E.A., Rutjes, F.P.J.T., Koide, K., Sato, M. & Unterstellar, E. Total synthesis of truncated brevetoxin B [AFGHIJK]. J. Am. Chem. Soc. 1994, 116, 9371.

Nicolaou, K.C., Bunnage, M.E., Koide, K. Total synthesis of balanol. K. Koide, J. Am. Chem. Soc.1994, 116, 8402.

Piscopio, A.D., Minowa, N., Chakraborty, T.K., Koide, K., Bertinato, P. & Nicolaou, K.C. A highly convergent strategy towards rapamycin. Stereoselective construction of the C8-C18 fragment. J. Chem. Soc. Chem. Commun. 1993, 7, 617.

Koide, K., Ohno, M., & Kobayashi, S. A new glycosylation reaction based on a remote activation concept – Glycosyl 2-pyridinecarboxylate as a novel glycosyl donor. Tetrahedron Lett. 1991, 32, 7065.

Kobayashi, S., Koide, K. & Ohno, M. Gallium reagents in organic synthesis: Dimethylgallium chloride and triflate as activators in glycosidation using glycopyranosyl fluorides.Tetrahedron Lett. 1990, 31, 2435.